diff --git a/error.go b/error.go
index 8c811966..8013de44 100644
--- a/error.go
+++ b/error.go
@@ -22,6 +22,12 @@ var ErrPoolExhausted = pool.ErrPoolExhausted
 // ErrPoolTimeout timed out waiting to get a connection from the connection pool.
 var ErrPoolTimeout = pool.ErrPoolTimeout
 
+// ErrCrossSlot is returned when keys are used in the same Redis command and
+// the keys are not in the same hash slot. This error is returned by Redis
+// Cluster and will be returned by the client when TxPipeline or TxPipelined
+// is used on a ClusterClient with keys in different slots.
+var ErrCrossSlot = proto.RedisError("CROSSSLOT Keys in request don't hash to the same slot")
+
 // HasErrorPrefix checks if the err is a Redis error and the message contains a prefix.
 func HasErrorPrefix(err error, prefix string) bool {
 	var rErr Error
diff --git a/osscluster.go b/osscluster.go
index 804f59c1..55017d8b 100644
--- a/osscluster.go
+++ b/osscluster.go
@@ -1509,6 +1509,10 @@ func (c *ClusterClient) processTxPipeline(ctx context.Context, cmds []Cmder) err
 	// Trim multi .. exec.
 	cmds = cmds[1 : len(cmds)-1]
 
+	if len(cmds) == 0 {
+		return nil
+	}
+
 	state, err := c.state.Get(ctx)
 	if err != nil {
 		setCmdsErr(cmds, err)
@@ -1516,6 +1520,12 @@ func (c *ClusterClient) processTxPipeline(ctx context.Context, cmds []Cmder) err
 	}
 
 	cmdsMap := c.mapCmdsBySlot(cmds)
+	// TxPipeline does not support cross slot transaction.
+	if len(cmdsMap) > 1 {
+		setCmdsErr(cmds, ErrCrossSlot)
+		return ErrCrossSlot
+	}
+
 	for slot, cmds := range cmdsMap {
 		node, err := state.slotMasterNode(slot)
 		if err != nil {
diff --git a/osscluster_test.go b/osscluster_test.go
index 99341183..10023218 100644
--- a/osscluster_test.go
+++ b/osscluster_test.go
@@ -462,8 +462,7 @@ var _ = Describe("ClusterClient", func() {
 		Describe("pipelining", func() {
 			var pipe *redis.Pipeline
 
-			assertPipeline := func() {
-				keys := []string{"A", "B", "C", "D", "E", "F", "G"}
+			assertPipeline := func(keys []string) {
 
 				It("follows redirects", func() {
 					if !failover {
@@ -482,13 +481,12 @@ var _ = Describe("ClusterClient", func() {
 					Expect(err).NotTo(HaveOccurred())
 					Expect(cmds).To(HaveLen(14))
 
-					_ = client.ForEachShard(ctx, func(ctx context.Context, node *redis.Client) error {
-						defer GinkgoRecover()
-						Eventually(func() int64 {
-							return node.DBSize(ctx).Val()
-						}, 30*time.Second).ShouldNot(BeZero())
-						return nil
-					})
+					// Check that all keys are set.
+					for _, key := range keys {
+						Eventually(func() string {
+							return client.Get(ctx, key).Val()
+						}, 30*time.Second).Should(Equal(key + "_value"))
+					}
 
 					if !failover {
 						for _, key := range keys {
@@ -517,14 +515,14 @@ var _ = Describe("ClusterClient", func() {
 				})
 
 				It("works with missing keys", func() {
-					pipe.Set(ctx, "A", "A_value", 0)
-					pipe.Set(ctx, "C", "C_value", 0)
+					pipe.Set(ctx, "A{s}", "A_value", 0)
+					pipe.Set(ctx, "C{s}", "C_value", 0)
 					_, err := pipe.Exec(ctx)
 					Expect(err).NotTo(HaveOccurred())
 
-					a := pipe.Get(ctx, "A")
-					b := pipe.Get(ctx, "B")
-					c := pipe.Get(ctx, "C")
+					a := pipe.Get(ctx, "A{s}")
+					b := pipe.Get(ctx, "B{s}")
+					c := pipe.Get(ctx, "C{s}")
 					cmds, err := pipe.Exec(ctx)
 					Expect(err).To(Equal(redis.Nil))
 					Expect(cmds).To(HaveLen(3))
@@ -547,7 +545,8 @@ var _ = Describe("ClusterClient", func() {
 
 				AfterEach(func() {})
 
-				assertPipeline()
+				keys := []string{"A", "B", "C", "D", "E", "F", "G"}
+				assertPipeline(keys)
 
 				It("doesn't fail node with context.Canceled error", func() {
 					ctx, cancel := context.WithCancel(context.Background())
@@ -590,7 +589,25 @@ var _ = Describe("ClusterClient", func() {
 
 				AfterEach(func() {})
 
-				assertPipeline()
+				// TxPipeline doesn't support cross slot commands.
+				// Use hashtag to force all keys to the same slot.
+				keys := []string{"A{s}", "B{s}", "C{s}", "D{s}", "E{s}", "F{s}", "G{s}"}
+				assertPipeline(keys)
+
+				// make sure CrossSlot error is returned
+				It("returns CrossSlot error", func() {
+					pipe.Set(ctx, "A{s}", "A_value", 0)
+					pipe.Set(ctx, "B{t}", "B_value", 0)
+					Expect(hashtag.Slot("A{s}")).NotTo(Equal(hashtag.Slot("B{t}")))
+					_, err := pipe.Exec(ctx)
+					Expect(err).To(MatchError(redis.ErrCrossSlot))
+				})
+
+				// doesn't fail when no commands are queued
+				It("returns no error when there are no commands", func() {
+					_, err := pipe.Exec(ctx)
+					Expect(err).NotTo(HaveOccurred())
+				})
 			})
 		})