diff --git a/scripts/generate_config_tests.py b/scripts/generate_config_tests.py
index 074b0e9d04..8121d1b2de 100755
--- a/scripts/generate_config_tests.py
+++ b/scripts/generate_config_tests.py
@@ -58,7 +58,7 @@ SUPER_SETTINGS = {
     'MBEDTLS_NO_PLATFORM_ENTROPY': 'MBEDTLS_ENTROPY_C',
     'MBEDTLS_PKCS1_V15': 'MBEDTLS_RSA_C',
     'MBEDTLS_PKCS1_V21': 'MBEDTLS_RSA_C',
-    'MBEDTLS_PSA_CRYPTO_CLIENT': 'MBEDTLS_PSA_CRYPTO_C',
+    'MBEDTLS_PSA_CRYPTO_CLIENT': '!MBEDTLS_PSA_CRYPTO_C',
     'MBEDTLS_PSA_INJECT_ENTROPY': 'MBEDTLS_PSA_CRYPTO_C',
     'MBEDTLS_PSA_ASSUME_EXCLUSIVE_BUFFERS': 'MBEDTLS_PSA_CRYPTO_C',
 }