diff --git a/tests/scripts/generate_psa_wrappers.py b/tests/scripts/generate_psa_wrappers.py
index d7970c0e37..c0ddebb50b 100755
--- a/tests/scripts/generate_psa_wrappers.py
+++ b/tests/scripts/generate_psa_wrappers.py
@@ -153,6 +153,9 @@ class PSAWrapperGenerator(c_wrapper_generator.Base):
         # Proof-of-concept: just instrument one function for now
         if function_name == 'psa_cipher_encrypt':
             return True
+        if function_name in ('psa_key_derivation_output_bytes',
+                             'psa_key_derivation_input_bytes'):
+            return True
         if function_name in ('psa_import_key',
                              'psa_export_key',
                              'psa_export_public_key'):
diff --git a/tests/src/psa_test_wrappers.c b/tests/src/psa_test_wrappers.c
index c074e8d7cc..301d374a79 100644
--- a/tests/src/psa_test_wrappers.c
+++ b/tests/src/psa_test_wrappers.c
@@ -438,7 +438,13 @@ psa_status_t mbedtls_test_wrap_psa_key_derivation_input_bytes(
     const uint8_t *arg2_data,
     size_t arg3_data_length)
 {
+#if defined(MBEDTLS_PSA_COPY_CALLER_BUFFERS)
+    MBEDTLS_TEST_MEMORY_POISON(arg2_data, arg3_data_length);
+#endif /* defined(MBEDTLS_PSA_COPY_CALLER_BUFFERS) */
     psa_status_t status = (psa_key_derivation_input_bytes)(arg0_operation, arg1_step, arg2_data, arg3_data_length);
+#if defined(MBEDTLS_PSA_COPY_CALLER_BUFFERS)
+    MBEDTLS_TEST_MEMORY_UNPOISON(arg2_data, arg3_data_length);
+#endif /* defined(MBEDTLS_PSA_COPY_CALLER_BUFFERS) */
     return status;
 }
 
@@ -470,7 +476,13 @@ psa_status_t mbedtls_test_wrap_psa_key_derivation_output_bytes(
     uint8_t *arg1_output,
     size_t arg2_output_length)
 {
+#if defined(MBEDTLS_PSA_COPY_CALLER_BUFFERS)
+    MBEDTLS_TEST_MEMORY_POISON(arg1_output, arg2_output_length);
+#endif /* defined(MBEDTLS_PSA_COPY_CALLER_BUFFERS) */
     psa_status_t status = (psa_key_derivation_output_bytes)(arg0_operation, arg1_output, arg2_output_length);
+#if defined(MBEDTLS_PSA_COPY_CALLER_BUFFERS)
+    MBEDTLS_TEST_MEMORY_UNPOISON(arg1_output, arg2_output_length);
+#endif /* defined(MBEDTLS_PSA_COPY_CALLER_BUFFERS) */
     return status;
 }