diff --git a/ChangeLog.d/8372.txt b/ChangeLog.d/8372.txt
new file mode 100644
index 0000000000..4a72edfb1a
--- /dev/null
+++ b/ChangeLog.d/8372.txt
@@ -0,0 +1,3 @@
+Features
+   *  AES-NI is now supported in Windows builds with clang and clang-cl.
+      Resolves #8372.
diff --git a/include/mbedtls/aesni.h b/include/mbedtls/aesni.h
index 0da40a0a3c..c9fe2bf356 100644
--- a/include/mbedtls/aesni.h
+++ b/include/mbedtls/aesni.h
@@ -58,7 +58,7 @@
  *       macros that may change in future releases.
  */
 #undef MBEDTLS_AESNI_HAVE_INTRINSICS
-#if defined(_MSC_VER)
+#if defined(_MSC_VER) && !defined(__clang__)
 /* Visual Studio supports AESNI intrinsics since VS 2008 SP1. We only support
  * VS 2013 and up for other reasons anyway, so no need to check the version. */
 #define MBEDTLS_AESNI_HAVE_INTRINSICS
@@ -66,7 +66,7 @@
 /* GCC-like compilers: currently, we only support intrinsics if the requisite
  * target flag is enabled when building the library (e.g. `gcc -mpclmul -msse2`
  * or `clang -maes -mpclmul`). */
-#if defined(__GNUC__) && defined(__AES__) && defined(__PCLMUL__)
+#if (defined(__GNUC__) || defined(__clang__)) && defined(__AES__) && defined(__PCLMUL__)
 #define MBEDTLS_AESNI_HAVE_INTRINSICS
 #endif
 
diff --git a/library/aesni.c b/library/aesni.c
index 77c1f9024b..3f62a2ed72 100644
--- a/library/aesni.c
+++ b/library/aesni.c
@@ -193,7 +193,7 @@ void mbedtls_aesni_gcm_mult(unsigned char c[16],
                             const unsigned char a[16],
                             const unsigned char b[16])
 {
-    __m128i aa, bb, cc, dd;
+    __m128i aa = { 0 }, bb = { 0 }, cc, dd;
 
     /* The inputs are in big-endian order, so byte-reverse them */
     for (size_t i = 0; i < 16; i++) {