diff --git a/src/tools/msvc/Mkvcbuild.pm b/src/tools/msvc/Mkvcbuild.pm
index 05ff67e693b..9b6539fb15d 100644
--- a/src/tools/msvc/Mkvcbuild.pm
+++ b/src/tools/msvc/Mkvcbuild.pm
@@ -587,6 +587,9 @@ sub mkvcbuild
 
 		# hack to prevent duplicate definitions of uid_t/gid_t
 		push(@perl_embed_ccflags, 'PLPERL_HAVE_UID_GID');
+		# prevent binary mismatch between MSVC built plperl and
+		# Strawberry or msys ucrt perl libraries
+		push(@perl_embed_ccflags, 'NO_THREAD_SAFE_LOCALE');
 
 		# Windows offers several 32-bit ABIs.  Perl is sensitive to
 		# sizeof(time_t), one of the ABI dimensions.  To get 32-bit time_t,