diff --git a/src/backend/storage/aio/aio_io.c b/src/backend/storage/aio/aio_io.c
index 36d2c1f492d..cc6d999a6fb 100644
--- a/src/backend/storage/aio/aio_io.c
+++ b/src/backend/storage/aio/aio_io.c
@@ -159,6 +159,12 @@ pgaio_io_before_prep(PgAioHandle *ioh)
 	Assert(pgaio_my_backend->handed_out_io == ioh);
 	Assert(pgaio_io_has_target(ioh));
 	Assert(ioh->op == PGAIO_OP_INVALID);
+
+	/*
+	 * Otherwise the FDs referenced by the IO could be closed due to interrupt
+	 * processing.
+	 */
+	Assert(!INTERRUPTS_CAN_BE_PROCESSED());
 }
 
 /*
diff --git a/src/backend/storage/aio/method_worker.c b/src/backend/storage/aio/method_worker.c
index 2be6bb8972b..4a7853d13fa 100644
--- a/src/backend/storage/aio/method_worker.c
+++ b/src/backend/storage/aio/method_worker.c
@@ -476,6 +476,13 @@ IoWorkerMain(const void *startup_data, size_t startup_data_len)
 						   "worker %d processing IO",
 						   MyIoWorkerId);
 
+			/*
+			 * Prevent interrupts between pgaio_io_reopen() and
+			 * pgaio_io_perform_synchronously() that otherwise could lead to
+			 * the FD getting closed in that window.
+			 */
+			HOLD_INTERRUPTS();
+
 			/*
 			 * It's very unlikely, but possible, that reopen fails. E.g. due
 			 * to memory allocations failing or file permissions changing or
@@ -502,6 +509,8 @@ IoWorkerMain(const void *startup_data, size_t startup_data_len)
 			 * ensure we don't accidentally fail.
 			 */
 			pgaio_io_perform_synchronously(ioh);
+
+			RESUME_INTERRUPTS();
 		}
 		else
 		{