diff --git a/src/tools/msvc/Mkvcbuild.pm b/src/tools/msvc/Mkvcbuild.pm
index 990c223a9b4..f86a065375f 100644
--- a/src/tools/msvc/Mkvcbuild.pm
+++ b/src/tools/msvc/Mkvcbuild.pm
@@ -582,7 +582,9 @@ sub mkvcbuild
 		push(@perl_embed_ccflags, 'PLPERL_HAVE_UID_GID');
 		# prevent binary mismatch between MSVC built plperl and
 		# Strawberry or msys ucrt perl libraries
-		push(@perl_embed_ccflags, 'NO_THREAD_SAFE_LOCALE');
+		my $perl_v = `$^X -V 2>&1`;
+		push(@perl_embed_ccflags, 'NO_THREAD_SAFE_LOCALE')
+		  unless $perl_v =~ /USE_THREAD_SAFE_LOCALE/;
 
 		# Windows offers several 32-bit ABIs.  Perl is sensitive to
 		# sizeof(time_t), one of the ABI dimensions.  To get 32-bit time_t,