diff --git a/mysql-test/suite/galera/r/galera_var_replicate_myisam_on.result b/mysql-test/suite/galera/r/galera_var_replicate_myisam_on.result
index 716af033e7a..ad28f5a426e 100644
--- a/mysql-test/suite/galera/r/galera_var_replicate_myisam_on.result
+++ b/mysql-test/suite/galera/r/galera_var_replicate_myisam_on.result
@@ -107,6 +107,135 @@ i
 1
 DROP TABLE t1;
 connection node_1;
-SET GLOBAL wsrep_replicate_myisam = 0;
+CREATE TABLE t1 (id INT NOT NULL PRIMARY KEY, b INT) ENGINE=MyISAM;
+INSERT INTO t1 values (1,1),(2,2),(3,3),(4,4),(5,5),(6,6),(7,7),(8,8),(9,9),(10,10);
+PREPARE upd from 'update t1 set b = 100 where id = 5';
+PREPARE ins from 'insert into t1 values (11,11)';
+PREPARE del from 'delete from t1 where id = 4';
+PREPARE rep from 'replace into t1 values (12,12),(6,600)';
+EXECUTE upd;
+EXECUTE ins;
+EXECUTE del;
+EXECUTE rep;
+SELECT * FROM t1 ORDER BY id;
+id	b
+1	1
+2	2
+3	3
+5	100
+6	600
+7	7
+8	8
+9	9
+10	10
+11	11
+12	12
+connection node_2;
+SELECT * FROM t1 ORDER BY id;
+id	b
+1	1
+2	2
+3	3
+5	100
+6	600
+7	7
+8	8
+9	9
+10	10
+11	11
+12	12
+DROP TABLE t1;
+connection node_1;
+CREATE TABLE t1 (id INT NOT NULL PRIMARY KEY, b INT) ENGINE=MyISAM;
+INSERT INTO t1 values (1,1),(2,2),(3,3),(4,4),(5,5),(6,6),(7,7),(8,8),(9,9),(10,10);
+CREATE PROCEDURE proc()
+BEGIN
+UPDATE t1 set b = 100 WHERE id = 5;
+INSERT INTO t1 VALUES (11,11);
+DELETE FROM t1 WHERE id = 4;
+REPLACE INTO t1 VALUES (12,12),(6,600);
+COMMIT;
+END|
+CALL proc();
+SELECT * FROM t1 ORDER BY id;
+id	b
+1	1
+2	2
+3	3
+5	100
+6	600
+7	7
+8	8
+9	9
+10	10
+11	11
+12	12
+connection node_2;
+SELECT * FROM t1 ORDER BY id;
+id	b
+1	1
+2	2
+3	3
+5	100
+6	600
+7	7
+8	8
+9	9
+10	10
+11	11
+12	12
+DROP PROCEDURE proc;
+DROP TABLE t1;
+connection node_1;
+CREATE TABLE t1 (id INT NOT NULL PRIMARY KEY, b INT) ENGINE=MyISAM;
+CREATE TABLE t2 (id INT NOT NULL PRIMARY KEY AUTO_INCREMENT, b INT) ENGINE=MyISAM;
+INSERT INTO t1 values (1,1),(2,2),(3,3),(4,4),(5,5),(6,6),(7,7),(8,8),(9,9),(10,10);
+CREATE TRIGGER tr1 BEFORE INSERT ON t1 FOR EACH ROW INSERT INTO t2 VALUES (NULL, NEW.b);
+CREATE TRIGGER tr2 BEFORE UPDATE ON t1 FOR EACH ROW INSERT INTO t2 VALUES (NULL, OLD.b),(NULL, NEW.b);
+CREATE TRIGGER tr3 BEFORE DELETE ON t1 FOR EACH ROW INSERT INTO t2 VALUES (NULL, OLD.b);
+INSERT INTO t1 VALUES (11,11);
+UPDATE t1 SET b = 200 WHERE id = 2;
+DELETE FROM t1 where id = 5;
+SELECT * FROM t1 ORDER BY id;
+id	b
+1	1
+2	200
+3	3
+4	4
+6	6
+7	7
+8	8
+9	9
+10	10
+11	11
+SELECT * FROM t2 ORDER BY id;
+id	b
+1	11
+2	2
+3	200
+4	5
+connection node_2;
+SELECT * FROM t1 ORDER BY id;
+id	b
+1	1
+2	200
+3	3
+4	4
+6	6
+7	7
+8	8
+9	9
+10	10
+11	11
+SELECT * FROM t2 ORDER BY id;
+id	b
+1	11
+2	2
+3	200
+4	5
+DROP TRIGGER tr1;
+DROP TRIGGER tr2;
+DROP TRIGGER tr3;
+DROP TABLE t1,t2;
+connection node_1;
 connection node_2;
-SET GLOBAL wsrep_replicate_myisam = 0;
diff --git a/mysql-test/suite/galera/t/galera_var_replicate_myisam_on.test b/mysql-test/suite/galera/t/galera_var_replicate_myisam_on.test
index 90c786f0af0..adb5cb04273 100644
--- a/mysql-test/suite/galera/t/galera_var_replicate_myisam_on.test
+++ b/mysql-test/suite/galera/t/galera_var_replicate_myisam_on.test
@@ -142,8 +142,88 @@ INSERT INTO t1 VALUES(1);
 SELECT * FROM t1;
 DROP TABLE t1;
 
+#
+# Test prepared staments
+#
 --connection node_1
---eval SET GLOBAL wsrep_replicate_myisam = $wsrep_replicate_myisam_orig
+CREATE TABLE t1 (id INT NOT NULL PRIMARY KEY, b INT) ENGINE=MyISAM;
+INSERT INTO t1 values (1,1),(2,2),(3,3),(4,4),(5,5),(6,6),(7,7),(8,8),(9,9),(10,10);
+
+PREPARE upd from 'update t1 set b = 100 where id = 5';
+PREPARE ins from 'insert into t1 values (11,11)';
+PREPARE del from 'delete from t1 where id = 4';
+PREPARE rep from 'replace into t1 values (12,12),(6,600)';
+
+EXECUTE upd;
+EXECUTE ins;
+EXECUTE del;
+EXECUTE rep;
+
+SELECT * FROM t1 ORDER BY id;
 
 --connection node_2
+SELECT * FROM t1 ORDER BY id;
+
+DROP TABLE t1;
+
+#
+# Test procedure
+#
+--connection node_1
+CREATE TABLE t1 (id INT NOT NULL PRIMARY KEY, b INT) ENGINE=MyISAM;
+INSERT INTO t1 values (1,1),(2,2),(3,3),(4,4),(5,5),(6,6),(7,7),(8,8),(9,9),(10,10);
+
+DELIMITER |;
+CREATE PROCEDURE proc()
+BEGIN
+  UPDATE t1 set b = 100 WHERE id = 5;
+  INSERT INTO t1 VALUES (11,11);
+  DELETE FROM t1 WHERE id = 4;
+  REPLACE INTO t1 VALUES (12,12),(6,600);
+  COMMIT;
+END|
+DELIMITER ;|
+
+CALL proc();
+SELECT * FROM t1 ORDER BY id;
+
+--connection node_2
+SELECT * FROM t1 ORDER BY id;
+
+DROP PROCEDURE proc;
+DROP TABLE t1;
+
+#
+# Test trigger
+#
+--connection node_1
+CREATE TABLE t1 (id INT NOT NULL PRIMARY KEY, b INT) ENGINE=MyISAM;
+CREATE TABLE t2 (id INT NOT NULL PRIMARY KEY AUTO_INCREMENT, b INT) ENGINE=MyISAM;
+INSERT INTO t1 values (1,1),(2,2),(3,3),(4,4),(5,5),(6,6),(7,7),(8,8),(9,9),(10,10);
+CREATE TRIGGER tr1 BEFORE INSERT ON t1 FOR EACH ROW INSERT INTO t2 VALUES (NULL, NEW.b);
+CREATE TRIGGER tr2 BEFORE UPDATE ON t1 FOR EACH ROW INSERT INTO t2 VALUES (NULL, OLD.b),(NULL, NEW.b);
+CREATE TRIGGER tr3 BEFORE DELETE ON t1 FOR EACH ROW INSERT INTO t2 VALUES (NULL, OLD.b);
+
+INSERT INTO t1 VALUES (11,11);
+UPDATE t1 SET b = 200 WHERE id = 2;
+DELETE FROM t1 where id = 5;
+SELECT * FROM t1 ORDER BY id;
+SELECT * FROM t2 ORDER BY id;
+
+--connection node_2
+SELECT * FROM t1 ORDER BY id;
+SELECT * FROM t2 ORDER BY id;
+DROP TRIGGER tr1;
+DROP TRIGGER tr2;
+DROP TRIGGER tr3;
+DROP TABLE t1,t2;
+
+--connection node_1
+--disable_query_log
 --eval SET GLOBAL wsrep_replicate_myisam = $wsrep_replicate_myisam_orig
+--enable_query_log
+
+--connection node_2
+--disable_query_log
+--eval SET GLOBAL wsrep_replicate_myisam = $wsrep_replicate_myisam_orig
+--enable_query_log
diff --git a/mysql-test/suite/wsrep/r/mdev_22681.result b/mysql-test/suite/wsrep/r/mdev_22681.result
new file mode 100644
index 00000000000..ecce324ead6
--- /dev/null
+++ b/mysql-test/suite/wsrep/r/mdev_22681.result
@@ -0,0 +1,3 @@
+CREATE TABLE t1 (a INT) ENGINE=InnoDB;
+EXECUTE IMMEDIATE 'CREATE OR REPLACE TABLE t1 ENGINE=InnoDB AS SELECT 1 AS b';
+DROP TABLE t1;
diff --git a/mysql-test/suite/wsrep/t/mdev_22681.cnf b/mysql-test/suite/wsrep/t/mdev_22681.cnf
new file mode 100644
index 00000000000..2f310476733
--- /dev/null
+++ b/mysql-test/suite/wsrep/t/mdev_22681.cnf
@@ -0,0 +1,10 @@
+!include ../my.cnf
+
+[mysqld.1]
+wsrep-on=ON
+log-bin
+binlog-format=ROW
+innodb-flush-log-at-trx-commit=1
+wsrep-cluster-address=gcomm://
+wsrep-provider=@ENV.WSREP_PROVIDER
+innodb-autoinc-lock-mode=2
diff --git a/mysql-test/suite/wsrep/t/mdev_22681.test b/mysql-test/suite/wsrep/t/mdev_22681.test
new file mode 100644
index 00000000000..ce1129c7485
--- /dev/null
+++ b/mysql-test/suite/wsrep/t/mdev_22681.test
@@ -0,0 +1,15 @@
+#
+# MDEV-22681: Server crashes in galera::ReplicatorSMM::CommitOrder::CommitOrder
+#            or assertion failed in wsrep::transaction::before_prepare.
+#
+# EXECUTE IMMEDIATE 'CREATE OR REPLACE TABLE t1 ENGINE=InnoDB AS SELECT 1 AS b'
+# crashes the server if binlog is on (see mdev_22681.cnf for configuration).
+#
+--source include/have_wsrep.inc
+--source include/have_wsrep_provider.inc
+--source include/have_innodb.inc
+
+CREATE TABLE t1 (a INT) ENGINE=InnoDB;
+EXECUTE IMMEDIATE 'CREATE OR REPLACE TABLE t1 ENGINE=InnoDB AS SELECT 1 AS b';
+
+DROP TABLE t1;
diff --git a/sql/sql_parse.cc b/sql/sql_parse.cc
index e8c94c6b363..05a1ee57d63 100644
--- a/sql/sql_parse.cc
+++ b/sql/sql_parse.cc
@@ -3792,6 +3792,7 @@ mysql_execute_command(THD *thd)
       lex->sql_command != SQLCOM_BEGIN    &&
       lex->sql_command != SQLCOM_CALL     &&
       lex->sql_command != SQLCOM_EXECUTE  &&
+      lex->sql_command != SQLCOM_EXECUTE_IMMEDIATE &&
       !(sql_command_flags[lex->sql_command] & CF_AUTO_COMMIT_TRANS))
   {
     wsrep_start_trx_if_not_started(thd);