diff --git a/mysql-test/suite/innodb/r/innodb_stats_fetch.result b/mysql-test/suite/innodb/r/innodb_stats_fetch.result
index df6bc4b0cf7..cb205b1827b 100644
--- a/mysql-test/suite/innodb/r/innodb_stats_fetch.result
+++ b/mysql-test/suite/innodb/r/innodb_stats_fetch.result
@@ -174,3 +174,10 @@ SELECT * FROM INFORMATION_SCHEMA.INNODB_SYS_VIRTUAL LIMIT ROWS EXAMINED 5;
 SELECT * FROM INFORMATION_SCHEMA.INNODB_SYS_FOREIGN LIMIT ROWS EXAMINED 5;
 SELECT * FROM INFORMATION_SCHEMA.INNODB_SYS_FOREIGN_COLS LIMIT ROWS EXAMINED 5;
 DROP TABLE t1;
+#
+# MDEV-33462 Disallow LOCK=NONE operation on statistics table
+#
+ALTER TABLE mysql.innodb_table_stats FORCE, LOCK=NONE;
+ERROR 0A000: LOCK=NONE is not supported. Reason: innodb_table_stats. Try LOCK=SHARED
+ALTER TABLE mysql.innodb_index_stats FORCE, LOCK=NONE;
+ERROR 0A000: LOCK=NONE is not supported. Reason: innodb_index_stats. Try LOCK=SHARED
diff --git a/mysql-test/suite/innodb/t/innodb_stats_fetch.test b/mysql-test/suite/innodb/t/innodb_stats_fetch.test
index 99fc115af1d..d02cd3b8959 100644
--- a/mysql-test/suite/innodb/t/innodb_stats_fetch.test
+++ b/mysql-test/suite/innodb/t/innodb_stats_fetch.test
@@ -96,3 +96,11 @@ SELECT * FROM INFORMATION_SCHEMA.INNODB_SYS_VIRTUAL LIMIT ROWS EXAMINED 5;
 SELECT * FROM INFORMATION_SCHEMA.INNODB_SYS_FOREIGN LIMIT ROWS EXAMINED 5;
 SELECT * FROM INFORMATION_SCHEMA.INNODB_SYS_FOREIGN_COLS LIMIT ROWS EXAMINED 5;
 DROP TABLE t1;
+
+--echo #
+--echo # MDEV-33462 Disallow LOCK=NONE operation on statistics table
+--echo #
+--error ER_ALTER_OPERATION_NOT_SUPPORTED_REASON
+ALTER TABLE mysql.innodb_table_stats FORCE, LOCK=NONE;
+--error ER_ALTER_OPERATION_NOT_SUPPORTED_REASON
+ALTER TABLE mysql.innodb_index_stats FORCE, LOCK=NONE;
diff --git a/storage/innobase/handler/handler0alter.cc b/storage/innobase/handler/handler0alter.cc
index 63778ddddb2..f278c428d62 100644
--- a/storage/innobase/handler/handler0alter.cc
+++ b/storage/innobase/handler/handler0alter.cc
@@ -2815,6 +2815,14 @@ cannot_create_many_fulltext_index:
 		}
 	}
 
+	if (m_prebuilt->table->is_stats_table()) {
+		if (ha_alter_info->online) {
+			ha_alter_info->unsupported_reason =
+				table_share->table_name.str;
+		}
+		online= false;
+	}
+
 	// FIXME: implement Online DDL for system-versioned operations
 	if (ha_alter_info->handler_flags & INNOBASE_ALTER_VERSIONED_REBUILD) {
 		if (ha_alter_info->online) {