diff --git a/mysql-test/suite/sql_sequence/replication_mixed.result b/mysql-test/suite/sql_sequence/replication_mixed.result
new file mode 100644
index 00000000000..f581d59fc30
--- /dev/null
+++ b/mysql-test/suite/sql_sequence/replication_mixed.result
@@ -0,0 +1,35 @@
+include/master-slave.inc
+[connection master]
+#
+# MDEV-16234
+# CREATE TABLE .. SELECT LASTVAL is written to binlog as single
+# statement, causes discrepancy between master and slave
+#
+CREATE SEQUENCE s1 ENGINE=InnoDB;
+SELECT NEXTVAL(s1);
+NEXTVAL(s1)
+1
+CREATE TABLE t1 ENGINE=InnoDB SELECT LASTVAL(s1) AS a;
+INSERT INTO t1 VALUES (NEXTVAL(s1));
+INSERT INTO t1 VALUES (LASTVAL(s1));
+SELECT * FROM t1;
+a
+1
+2
+2
+SELECT * from s1;
+next_not_cached_value	minimum_value	maximum_value	start_value	increment	cache_size	cycle_option	cycle_count
+1001	1	9223372036854775806	1	1	1000	0	0
+connection slave;
+SELECT * FROM t1;
+a
+1
+2
+2
+SELECT * from s1;
+next_not_cached_value	minimum_value	maximum_value	start_value	increment	cache_size	cycle_option	cycle_count
+1001	1	9223372036854775806	1	1	1000	0	0
+connection master;
+DROP TABLE t1;
+DROP SEQUENCE s1;
+include/rpl_end.inc
diff --git a/mysql-test/suite/sql_sequence/replication_mixed.test b/mysql-test/suite/sql_sequence/replication_mixed.test
new file mode 100644
index 00000000000..0096ab5acd8
--- /dev/null
+++ b/mysql-test/suite/sql_sequence/replication_mixed.test
@@ -0,0 +1,27 @@
+--source include/have_innodb.inc
+--source include/have_binlog_format_mixed.inc
+--source include/master-slave.inc
+
+--echo #
+--echo # MDEV-16234
+--echo # CREATE TABLE .. SELECT LASTVAL is written to binlog as single
+--echo # statement, causes discrepancy between master and slave
+--echo #
+
+CREATE SEQUENCE s1 ENGINE=InnoDB;
+SELECT NEXTVAL(s1);
+CREATE TABLE t1 ENGINE=InnoDB SELECT LASTVAL(s1) AS a;
+INSERT INTO t1 VALUES (NEXTVAL(s1));
+INSERT INTO t1 VALUES (LASTVAL(s1));
+SELECT * FROM t1;
+SELECT * from s1;
+--sync_slave_with_master
+SELECT * FROM t1;
+SELECT * from s1;
+
+# Cleanup
+--connection master
+DROP TABLE t1;
+DROP SEQUENCE s1;
+
+--source include/rpl_end.inc
diff --git a/sql/sql_lex.cc b/sql/sql_lex.cc
index 47557d562a8..db7e8e09be4 100644
--- a/sql/sql_lex.cc
+++ b/sql/sql_lex.cc
@@ -6791,6 +6791,7 @@ Item *LEX::create_item_func_nextval(THD *thd, Table_ident *table_ident)
                                                           TL_WRITE_ALLOW_WRITE,
                                                           MDL_SHARED_WRITE))))
     return NULL;
+  thd->lex->set_stmt_unsafe(LEX::BINLOG_STMT_UNSAFE_SYSTEM_FUNCTION);
   return new (thd->mem_root) Item_func_nextval(thd, table);
 }
 
@@ -6803,6 +6804,7 @@ Item *LEX::create_item_func_lastval(THD *thd, Table_ident *table_ident)
                                                           TL_READ,
                                                           MDL_SHARED_READ))))
     return NULL;
+  thd->lex->set_stmt_unsafe(LEX::BINLOG_STMT_UNSAFE_SYSTEM_FUNCTION);
   return new (thd->mem_root) Item_func_lastval(thd, table);
 }