diff --git a/mysql-test/main/vector2.result b/mysql-test/main/vector2.result
index 73125c1224c..be0f0e8315d 100644
--- a/mysql-test/main/vector2.result
+++ b/mysql-test/main/vector2.result
@@ -356,3 +356,16 @@ a	vec_totext(v)
 8	[33]
 9	[33]
 drop table t1;
+#
+# MDEV-35296 DESC does not work in ORDER BY with vector key
+#
+create table t (v vector(1) not null, vector(v));
+insert into t select vec_fromtext(concat('[',seq,']')) FROM seq_1_to_10;
+select vec_totext(v) from t order by vec_distance_euclidean(v,vec_fromtext('[0]')) desc limit 5;
+vec_totext(v)
+[10]
+[9]
+[8]
+[7]
+[6]
+drop table t;
diff --git a/mysql-test/main/vector2.test b/mysql-test/main/vector2.test
index 5e112f8a392..58319b675f5 100644
--- a/mysql-test/main/vector2.test
+++ b/mysql-test/main/vector2.test
@@ -257,3 +257,11 @@ update t1 set v = vec_fromtext(concat('[33]')) where a <= 15;
 --sorted_result
 select a, vec_totext(v) from t1 order by vec_distance_euclidean(v,vec_fromtext('[33]')) limit 25;
 drop table t1;
+
+--echo #
+--echo # MDEV-35296 DESC does not work in ORDER BY with vector key
+--echo #
+create table t (v vector(1) not null, vector(v));
+insert into t select vec_fromtext(concat('[',seq,']')) FROM seq_1_to_10;
+select vec_totext(v) from t order by vec_distance_euclidean(v,vec_fromtext('[0]')) desc limit 5;
+drop table t;
diff --git a/sql/sql_select.cc b/sql/sql_select.cc
index 9d390ebe531..9dda4edd168 100644
--- a/sql/sql_select.cc
+++ b/sql/sql_select.cc
@@ -26486,7 +26486,7 @@ static int test_if_order_by_key(JOIN *join, ORDER *order, TABLE *table,
 
   if ((*order->item)->real_item()->type() != Item::FIELD_ITEM)
   {
-    if (order->next)
+    if (order->next || order->direction != ORDER::ORDER_ASC)
       DBUG_RETURN(0);
 
     DBUG_RETURN((*order->item)->part_of_sortkey().is_set(idx));