diff --git a/mysql-test/main/vector2.result b/mysql-test/main/vector2.result
index b30babb1c6d..e1ed40d0774 100644
--- a/mysql-test/main/vector2.result
+++ b/mysql-test/main/vector2.result
@@ -395,4 +395,17 @@ flush tables;
 update t set v = 1;
 ERROR HY000: Cannot cast 'int' as 'vector' in assignment of `test`.`t`.`v`
 drop table t;
+#
+# MDEV-35792 Adding a regular index on a vector column leads to invalid table structure
+#
+create table t (v vector(800), key(v));
+ERROR 42000: Specified key was too long; max key length is 1000 bytes
+create table t (v vector(8), key(v));
+show create table t;
+Table	Create Table
+t	CREATE TABLE `t` (
+  `v` vector(8) DEFAULT NULL,
+  KEY `v` (`v`)
+) ENGINE=MyISAM DEFAULT CHARSET=utf8mb4 COLLATE=utf8mb4_uca1400_ai_ci
+drop table t;
 # End of 11.7 tests
diff --git a/mysql-test/main/vector2.test b/mysql-test/main/vector2.test
index 916792277b1..d63583f9c07 100644
--- a/mysql-test/main/vector2.test
+++ b/mysql-test/main/vector2.test
@@ -289,4 +289,13 @@ flush tables;
 update t set v = 1;
 drop table t;
 
+--echo #
+--echo # MDEV-35792 Adding a regular index on a vector column leads to invalid table structure
+--echo #
+--error ER_TOO_LONG_KEY
+create table t (v vector(800), key(v));
+create table t (v vector(8), key(v));
+show create table t;
+drop table t;
+
 --echo # End of 11.7 tests
diff --git a/sql/sql_table.cc b/sql/sql_table.cc
index 6f9a7c2019f..3d29d1115b3 100644
--- a/sql/sql_table.cc
+++ b/sql/sql_table.cc
@@ -3012,7 +3012,7 @@ my_bool init_key_part_spec(THD *thd, Alter_info *alter_info,
   }
   if (key_part_length > max_key_part_length)
   {
-    if (key.type == Key::MULTIPLE)
+    if (key.type == Key::MULTIPLE && type_handler->type_can_have_key_part())
     {
       key_part_length= max_key_part_length;
       /* not a critical problem */