diff --git a/mysql-test/mysql-test-run.pl b/mysql-test/mysql-test-run.pl
index a6179779bf3..74fdae1f8c5 100755
--- a/mysql-test/mysql-test-run.pl
+++ b/mysql-test/mysql-test-run.pl
@@ -3030,6 +3030,12 @@ sub mysql_install_db {
   mtr_add_arg($args, "--lc-messages-dir=%s", $install_lang);
   mtr_add_arg($args, "--character-sets-dir=%s", $install_chsdir);
 
+  # On some old linux kernels, aio on tmpfs is not supported
+  # Remove this if/when Bug #58421 fixes this in the server
+  if ($^O eq "linux" && $opt_mem) {
+    mtr_add_arg($args, "--loose-skip-innodb-use-native-aio");
+  }
+
   # InnoDB arguments that affect file location and sizes may
   # need to be given to the bootstrap process as well as the
   # server process.
@@ -4515,6 +4521,13 @@ sub mysqld_arguments ($$$) {
     }
   }
 
+  # On some old linux kernels, aio on tmpfs is not supported
+  # Remove this if/when Bug #58421 fixes this in the server
+  if ($^O eq "linux" && $opt_mem)
+  {
+    mtr_add_arg($args, "--loose-skip-innodb-use-native-aio");
+  }
+
   if ( $mysql_version_id >= 50106 && !$opt_user_args)
   {
     # Turn on logging to file