diff --git a/mysql-test/suite/rpl/r/rpl_parallel_seq.result b/mysql-test/suite/rpl/r/rpl_parallel_seq.result
index fdb6bfef724..2746aaaf8a5 100644
--- a/mysql-test/suite/rpl/r/rpl_parallel_seq.result
+++ b/mysql-test/suite/rpl/r/rpl_parallel_seq.result
@@ -121,7 +121,10 @@ SET @@global.debug_dbug = "";
 SET @@global.gtid_strict_mode=0;
 include/start_slave.inc
 connection master;
-DROP SEQUENCE s2,s3;
+BEGIN;
+INSERT INTO ti SET a=32593;
+CREATE SEQUENCE s4;
+DROP SEQUENCE s2,s3,s4;
 DROP TABLE ti;
 connection slave;
 include/rpl_end.inc
diff --git a/mysql-test/suite/rpl/t/rpl_parallel_seq.test b/mysql-test/suite/rpl/t/rpl_parallel_seq.test
index ecc29de779b..4c4e8297587 100644
--- a/mysql-test/suite/rpl/t/rpl_parallel_seq.test
+++ b/mysql-test/suite/rpl/t/rpl_parallel_seq.test
@@ -185,7 +185,12 @@ SET debug_sync = RESET;
 --source include/start_slave.inc
 
 --connection master
-DROP SEQUENCE s2,s3;
+# MDEV-32593 Assertion failure upon CREATE SEQUENCE
+BEGIN;
+INSERT INTO ti SET a=32593;
+CREATE SEQUENCE s4;
+
+DROP SEQUENCE s2,s3,s4;
 DROP TABLE ti;
 
 --sync_slave_with_master
diff --git a/sql/log_event.cc b/sql/log_event.cc
index 7c791a4b6f5..10bf569d636 100644
--- a/sql/log_event.cc
+++ b/sql/log_event.cc
@@ -8025,7 +8025,7 @@ Gtid_log_event::Gtid_log_event(THD *thd_arg, uint64 seq_no_arg,
     flags2|= (thd_arg->rgi_slave->gtid_ev_flags2 & (FL_DDL|FL_WAITED));
 
   DBUG_ASSERT(thd_arg->lex->sql_command != SQLCOM_CREATE_SEQUENCE ||
-              (flags2 & FL_DDL));
+              (flags2 & FL_DDL) || thd_arg->in_multi_stmt_transaction_mode());
 }