diff --git a/acme/setup.py b/acme/setup.py
index ce426cf74..51bbf0f71 100644
--- a/acme/setup.py
+++ b/acme/setup.py
@@ -19,9 +19,7 @@ install_requires = [
     'pyrfc3339',
     'pytz',
     'requests[security]>=2.4.1',  # security extras added in 2.4.1
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'six>=1.9.0',  # needed for python_2_unicode_compatible
 ]
 
diff --git a/certbot-apache/setup.py b/certbot-apache/setup.py
index 38f41e9f1..76d7f5ca5 100644
--- a/certbot-apache/setup.py
+++ b/certbot-apache/setup.py
@@ -12,9 +12,7 @@ install_requires = [
     'certbot=={0}'.format(version),
     'mock',
     'python-augeas',
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'zope.component',
     'zope.interface',
 ]
diff --git a/certbot-dns-cloudflare/setup.py b/certbot-dns-cloudflare/setup.py
index 612e7259f..e1b84d1be 100644
--- a/certbot-dns-cloudflare/setup.py
+++ b/certbot-dns-cloudflare/setup.py
@@ -12,9 +12,7 @@ install_requires = [
     'certbot=={0}'.format(version),
     'cloudflare>=1.5.1',
     'mock',
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'zope.interface',
 ]
 
diff --git a/certbot-dns-cloudxns/setup.py b/certbot-dns-cloudxns/setup.py
index 3157400c6..53ceb58ea 100644
--- a/certbot-dns-cloudxns/setup.py
+++ b/certbot-dns-cloudxns/setup.py
@@ -12,9 +12,7 @@ install_requires = [
     'certbot=={0}'.format(version),
     'dns-lexicon',
     'mock',
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'zope.interface',
 ]
 
diff --git a/certbot-dns-digitalocean/setup.py b/certbot-dns-digitalocean/setup.py
index 1a68400fa..3330bdd67 100644
--- a/certbot-dns-digitalocean/setup.py
+++ b/certbot-dns-digitalocean/setup.py
@@ -12,9 +12,7 @@ install_requires = [
     'certbot=={0}'.format(version),
     'mock',
     'python-digitalocean>=1.11',
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'six',
     'zope.interface',
 ]
diff --git a/certbot-dns-dnsimple/setup.py b/certbot-dns-dnsimple/setup.py
index 35de47308..00a3c032a 100644
--- a/certbot-dns-dnsimple/setup.py
+++ b/certbot-dns-dnsimple/setup.py
@@ -12,9 +12,7 @@ install_requires = [
     'certbot=={0}'.format(version),
     'dns-lexicon',
     'mock',
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'zope.interface',
 ]
 
diff --git a/certbot-dns-dnsmadeeasy/setup.py b/certbot-dns-dnsmadeeasy/setup.py
index a946d00a4..36119ade0 100644
--- a/certbot-dns-dnsmadeeasy/setup.py
+++ b/certbot-dns-dnsmadeeasy/setup.py
@@ -12,9 +12,7 @@ install_requires = [
     'certbot=={0}'.format(version),
     'dns-lexicon',
     'mock',
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'zope.interface',
 ]
 
diff --git a/certbot-dns-google/setup.py b/certbot-dns-google/setup.py
index 8585fc848..10fccd1ea 100644
--- a/certbot-dns-google/setup.py
+++ b/certbot-dns-google/setup.py
@@ -15,9 +15,7 @@ install_requires = [
     'mock',
     # for oauth2client.service_account.ServiceAccountCredentials
     'oauth2client>=2.0',
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'zope.interface',
     # already a dependency of google-api-python-client, but added for consistency
     'httplib2'
diff --git a/certbot-dns-luadns/setup.py b/certbot-dns-luadns/setup.py
index 4fec37e29..b094e1818 100644
--- a/certbot-dns-luadns/setup.py
+++ b/certbot-dns-luadns/setup.py
@@ -12,9 +12,7 @@ install_requires = [
     'certbot=={0}'.format(version),
     'dns-lexicon',
     'mock',
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'zope.interface',
 ]
 
diff --git a/certbot-dns-nsone/setup.py b/certbot-dns-nsone/setup.py
index dca9ebf27..e777d821b 100644
--- a/certbot-dns-nsone/setup.py
+++ b/certbot-dns-nsone/setup.py
@@ -12,9 +12,7 @@ install_requires = [
     'certbot=={0}'.format(version),
     'dns-lexicon',
     'mock',
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'zope.interface',
 ]
 
diff --git a/certbot-dns-rfc2136/setup.py b/certbot-dns-rfc2136/setup.py
index bfa72b50b..6fc6dca73 100644
--- a/certbot-dns-rfc2136/setup.py
+++ b/certbot-dns-rfc2136/setup.py
@@ -12,9 +12,7 @@ install_requires = [
     'certbot=={0}'.format(version),
     'dnspython',
     'mock',
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'zope.interface',
 ]
 
diff --git a/certbot-dns-route53/setup.py b/certbot-dns-route53/setup.py
index 8df687972..0fbeab31b 100644
--- a/certbot-dns-route53/setup.py
+++ b/certbot-dns-route53/setup.py
@@ -10,9 +10,7 @@ install_requires = [
     'certbot=={0}'.format(version),
     'boto3',
     'mock',
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'zope.interface',
 ]
 
diff --git a/certbot-nginx/setup.py b/certbot-nginx/setup.py
index 152f77de8..a84efe2c3 100644
--- a/certbot-nginx/setup.py
+++ b/certbot-nginx/setup.py
@@ -13,9 +13,7 @@ install_requires = [
     'mock',
     'PyOpenSSL',
     'pyparsing>=1.5.5',  # Python3 support; perhaps unnecessary?
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'zope.interface',
 ]
 
diff --git a/setup.py b/setup.py
index 47b5b0b2c..736ef467f 100644
--- a/setup.py
+++ b/setup.py
@@ -46,9 +46,7 @@ install_requires = [
     'parsedatetime>=1.3',  # Calendar.parseDT
     'pyrfc3339',
     'pytz',
-    # For pkg_resources. >=1.0 so pip resolves it to a version cryptography
-    # will tolerate; see #2599:
-    'setuptools>=1.0',
+    'setuptools',
     'zope.component',
     'zope.interface',
 ]