diff --git a/hardware/arduino/sam/variants/arduino_due_x/variant.h b/hardware/arduino/sam/variants/arduino_due_x/variant.h
index e7d720ff2..8ac0fd30f 100644
--- a/hardware/arduino/sam/variants/arduino_due_x/variant.h
+++ b/hardware/arduino/sam/variants/arduino_due_x/variant.h
@@ -119,13 +119,13 @@ static const uint8_t SCK  = PIN_SPI_SCK ;
 #define PIN_WIRE_SCL         (21u)
 #define WIRE_INTERFACE       TWI1
 #define WIRE_INTERFACE_ID    ID_TWI1
-#define WIRE_ISR_HANDLER     TWI1_IrqHandler
+#define WIRE_ISR_HANDLER     TWI1_Handler
 
 #define PIN_WIRE1_SDA        (70u)
 #define PIN_WIRE1_SCL        (71u)
 #define WIRE1_INTERFACE      TWI0
 #define WIRE1_INTERFACE_ID   ID_TWI0
-#define WIRE1_ISR_HANDLER    TWI0_IrqHandler
+#define WIRE1_ISR_HANDLER    TWI0_Handler
 
 /*
  * UART/USART Interfaces